CaMKIV/Gr is dispensable for spermatogenesis and CREM-regulated transcription in male germ cells-Reference-Cited by-同舟云学术

CaMKIV/Gr is dispensable for spermatogenesis and CREM-regulated transcription in male germ cells

Published:2001-11-01 Issue:5 Volume:281 Page:E931-E937
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Blaeser Frank¹,Toppari Jorma²³,Heikinheimo Markku¹⁴,Yan Wei³,Wallace Mia⁵,Ho Nga¹,Chatila Talal A.¹⁶⁷

Affiliation:

1. Departments of Pediatrics,

2. Pediatrics and

3. Physiology, University of Turku, 20520 Turku; and

4. Children's Hospital, University of Helsinki, 00290 Helsinki, Finland

5. Anatomy and Neurobiology, and

6. Pathology and Immunology, and

7. Center for Immunology, Washington University School of Medicine, St. Louis, Missouri 63110; Departments of

Abstract

The calcium/calmodulin-dependent protein kinase type IV/Gr (CaMKIV/Gr) is expressed in male germ cells and spermatids and has been implicated in controlling the differentiation of germ cells into mature spermatozoa. The function of CaMKIV/Gr in spermatogenesis was investigated using CaMKIV/Gr-deficient mice generated by targeted gene disruption. CaMKIV/Gr-deficient males exhibited normal spermatogenesis, and their fertility was similar to that of wild-type littermates. Notwithstanding the function of CaMKIV/Gr as an activator of cAMP response element (CRE)-dependent transcription, mRNA levels of several testis-specific CRE modulator (CREM)-regulated genes were unaltered. These results indicate that CaMKIV/Gr is not essential for spermatogenesis or for CRE-regulated gene transcription in the testis.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://www.physiology.org/doi/pdf/10.1152/ajpendo.2001.281.5.E931

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