GCN2 is required to maintain core body temperature in mice during acute cold-Reference-Cited by-同舟云学术

GCN2 is required to maintain core body temperature in mice during acute cold

Published:2023-11-01 Issue:5 Volume:325 Page:E624-E637
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Levy Jordan L.¹,Mirek Emily T.¹^ORCID,Rodriguez Esther M.¹,Zalma Brian¹,Burns Jeffrey¹,Jonsson William O.¹,Sampath Harini¹^ORCID,Staschke Kirk A.²³,Wek Ronald C.²³,Anthony Tracy G.¹^ORCID

Affiliation:

1. Department of Nutritional Sciences, New Jersey Institute for Food, Nutrition and Health, Rutgers University, New Brunswick, New Jersey, United States

2. Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States

3. Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, Indiana, United States

Abstract

This paper details the discovery that GCN2 activation is required in both male and female mice to maintain core body temperature during acute cold exposure. The results point to a novel role for GCN2 in supporting adaptive thermogenesis via amino acid transport and actomyosin mechanics in brown adipose tissue.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | NIH | National Institute of General Medical Sciences

IU | Melvin and Bren Simon Cancer Center, Indiana University

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00181.2023

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