Identification and functionalization of thyrotropin receptor antibodies with different antigenic epitopes-Reference-Cited by-同舟云学术

Identification and functionalization of thyrotropin receptor antibodies with different antigenic epitopes

Published:2024-09-01 Issue:3 Volume:327 Page:E328-E343
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Zheng Jingyi¹,Duan Honghong²,Jiang Zhengrong¹,Chen Lijun¹,You Sufang¹,Huang Linghong¹,Huang Huibin¹^ORCID

Affiliation:

1. Department of Endocrinology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, People’s Republic of China

2. Department of Gynaecology and Obstetrics, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, People’s Republic of China

Abstract

We identified six molecular targets of different types of AITD [GD, GO, GD(3), and HT(TRAb+)], which have diagnostic value for different types of AITD. Meanwhile, we found that TRAb with different antigenic epitopes extracted from the sera of patients with AITD had different biological functions, which also provided a new idea for further research on the mechanism of action of TRAb with different antigenic epitopes in AITD.

Funder

Fujian Provincial Department of Finance

福建省科技厅 | Natural Science Foundation of Fujian Province

Fujian Provincial Department of Science and Technology

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00123.2024

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