Low-protein diet-induced hyperphagia and adiposity are modulated through interactions involving thermoregulation, motor activity, and protein quality in mice

Author:

Blais Anne1,Chaumontet Catherine1,Azzout-Marniche Dalila1,Piedcoq Julien1,Fromentin Gilles1,Gaudichon Claire1,Tomé Daniel1,Even Patrick C.1

Affiliation:

1. UMR Physiologie de la Nutrition et du Comportement Alimentaire, AgroParisTech, Institut National de la Recherche Agronomique, Université Paris Saclay, Paris, France

Abstract

Low protein (LP)-containing diets can induce overeating in rodents and possibly in humans in an effort to meet protein requirement, but the effects on energy expenditure (EE) are unclear. The present study evaluated the changes induced by reducing dietary protein from 20% to 6%—using either soy protein or casein—on energy intake, body composition, and EE in mice housed at 22°C or at 30°C (thermal neutrality). LP feeding increased energy intake and adiposity, more in soy-fed than in casein-fed mice, but also increased EE, thus limiting fat accumulation. The increase in EE was due mainly to an increase in spontaneous motor activity related to EE and not to thermoregulation. However, the high cost of thermoregulation at 22°C and the subsequent heat exchanges between nonshivering thermogenesis, motor activity, and feeding induced large differences in adaptation between mice housed at 22°C and at 30°C.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

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