Precision and accuracy of hyperglycemic clamps in a multicenter study-Reference-Cited by-同舟云学术

Precision and accuracy of hyperglycemic clamps in a multicenter study

Published:2021-04-01 Issue:4 Volume:320 Page:E797-E807
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Mather Kieren J.¹^ORCID,Tjaden Ashley H.²,Hoehn Adam³,Nadeau Kristen J.⁴,Buchanan Thomas A.⁵,Kahn Steven E.⁶,Arslanian Silva A.⁷,Caprio Sonia⁸,Atkinson Karen M.⁶,Cree-Green Melanie⁴^ORCID,Utzschneider Kristina M.⁶,Edelstein Sharon L.²

Affiliation:

1. Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana

2. The Biostatistics Center, Milken Institute School of Public Health, George Washington University, Washington, DC

3. College of Osteopathic Medicine, Marian University, Indianapolis, Indiana

4. Department of Pediatrics, School of Medicine, University of Colorado Denver, Colorado

5. Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California

6. Department of Medicine, VA Puget Sound Health Care System, University of Washington, Seattle, Washington

7. Department of Pediatrics, School of Medicine, University of Pittsburgh, Pennsylvania

8. Department of Pediatrics, School of Medicine, Yale University, New Haven, Connecticut

Abstract

The Restoring Insulin Secretion (RISE) study centers undertook hyperglycemic clamps using a simplified methodology and a decision guidance algorithm implemented in an easy-to-use spreadsheet. This approach, combined with active management including ongoing central data surveillance and routine feedback to study centers, produced technically excellent standardization of achieved glucose concentrations on repeat studies within and across study centers.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00598.2020

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