Hepatic lipid droplet-associated proteome changes distinguish dietary-induced fatty liver from glucose tolerance in male mice-Reference-Cited by-同舟云学术

Hepatic lipid droplet-associated proteome changes distinguish dietary-induced fatty liver from glucose tolerance in male mice

Published:2024-06-01 Issue:6 Volume:326 Page:E842-E855
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Van Woerkom Andries¹,Harney Dylan J.¹²,Nagarajan Shilpa R.¹,Hakeem-Sanni Mariam F.¹,Lin Jinfeng¹,Hooke Matthew¹,Pulpitel Tamara²,Cooney Gregory J.¹,Larance Mark¹,Saunders Darren N.¹,Brandon Amanda E.¹²,Hoy Andrew J.¹^ORCID

Affiliation:

1. Faculty of Medicine and Health, School of Medical Sciences, Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia

2. Faculty of Science, School of Life and Environmental Sciences, Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia

Abstract

This study identified a fatty liver lipid droplet proteome and one associated with glucose tolerance. Notably, glucose intolerance was linked with changes in the ratio of adipose triglyceride lipase to perilipin 5 that is indicative of dysregulation of neutral lipid homeostasis.

Funder

University of Sydney

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00013.2024

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