Low dietary fiber promotes enteric expansion of a Crohn’s disease-associated pathobiont independent of obesity-Reference-Cited by-同舟云学术

Low dietary fiber promotes enteric expansion of a Crohn’s disease-associated pathobiont independent of obesity

Published:2021-09-01 Issue:3 Volume:321 Page:E338-E350
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Lau Trevor C.¹,Fiebig-Comyn Aline A.¹,Shaler Christopher R.¹,McPhee Joseph B.²,Coombes Brian K.¹³,Schertzer Jonathan D.¹³⁴^ORCID

Affiliation:

1. Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada

2. Department of Chemistry and Biology, Ryerson University, Toronto, Ontario, Canada

3. Farncombe Family Digestive Health Research Institute, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada

4. Centre for Metabolism, Obesity, and Diabetes Research, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada

Abstract

It is commonly thought that obesity or a high-fat diet alters pathogenic bacteria and promotes inflammatory gut diseases. We found that lower dietary fiber is a key factor that expands a gut pathobiont linked to Crohn’s disease, independent of obesity status in mice.

Funder

Crohn's and Colitis Canada

Gouvernement du Canada | Canadian Institutes of Health Research

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00134.2021

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