High NOV/CCN3 expression during high-fat diet pregnancy in mice affects GLUT3 expression and the mTOR pathway

Author:

Wang Hefei12,Huang Binbin12,Hou Anli34,Xue Li12,Wang Baobei12,Chen Jie12,Li Mengxia12,Zhang Jian V.12

Affiliation:

1. Center for Energy Metabolism and Reproduction, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, People’s Republic of China

2. Department of Clinical Pharmacy and Translational Medicine, School of Pharmacy and Biomedicine, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, People’s Republic of China

3. Department of Gynaecology, University of Chinese Academy of Sciences Shenzhen Hospital, Shenzhen, People’s Republic of China

4. Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, People’s Republic of China

Abstract

NOV/CCN3 regulates glucose homeostasis in mice during pregnancy. NOV/CCN3 upregulates GLUT3 expression and affects the mTOR pathway in the GDM environment in vivo and in vitro.

Funder

the National Key Research and Development Program of China

Key Program of National Natural Science Foundation of China

General Program of National Natural Science Foundation of China

Science and Technology Innovation Fund of Shenzhen

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

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