Repurposed major urinary protein pheromones and adult sensory neurons: roles in neuron plasticity and experimental diabetes-Reference-Cited by-同舟云学术

Repurposed major urinary protein pheromones and adult sensory neurons: roles in neuron plasticity and experimental diabetes

Published:2022-07-01 Issue:1 Volume:323 Page:E53-E68
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Poitras Trevor¹,Singh Vandana²,Piragasam Ramanaguru S.³,Wang Xiuling⁴⁵,Mannaa Atef M.⁶⁷,Chandrasekhar Ambika¹,Martinez Jose²,Fahlman Richard³,Zochodne Douglas W.¹²^ORCID

Affiliation:

1. Division of Neurology, Department of Medicine and the Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada

2. Division of Neurology, Department of Clinical Neuroscience and the Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada

3. Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada

4. Southern Alberta Microarray Facility, Department Biochemistry and Molecular. Biology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada

5. Department of Oncology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada

6. INSERM U1192, Laboratoire Protéomique, Réponse Inflammatoire & Spectrométrie de Masse (PRISM), Université de Lille, Lille, France

7. Higher Institute of Engineering and Technology, New Borg El-Arab City, Egypt

Abstract

New molecular mechanisms are important to unravel and understand diabetic polyneuropathy, a disorder prevalent in over half of persons with diabetes mellitus (DM). MUPs, members of the lipocalin family of molecules, have an unexpected impact on the plasticity of sensory neurons that are targeted in type 1 experimental diabetic neuropathy. This work explores this potential target in neuropathy in the context of the lipocalin family of molecules.

Funder

Gouvernement du Canada | Canadian Institutes of Health Research

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00001.2022

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