Vitamin D supplementation induces CatG-mediated CD4+ T cell inactivation and restores pancreatic β-cell function in mice with type 1 diabetes-Reference-Cited by-同舟云学术

Vitamin D supplementation induces CatG-mediated CD4+ T cell inactivation and restores pancreatic β-cell function in mice with type 1 diabetes

Published:2022-01-01 Issue:1 Volume:322 Page:E74-E84
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Lai Xiaoyang¹,Liu Xuyang¹,Cai Xia¹,Zou Fang¹^ORCID

Affiliation:

1. Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China

Abstract

We report that vitamin D (VD) supplementation downregulates CatG expression and inhibits CD4+ T cell activation, thereby improving β-cell function in type 1 diabetes (T1D). This study deepens our understanding of the pathogenesis of T1D and clarifies molecular events underlying the alleviatory effect of VD for immunotherapy against T1D.

Funder

Education Department of Jiangxi Province

Health Commission of Jiangxi Province

Jiangxi Provincial Department of Science and Technology

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00066.2021

Reference35 articles.

1. STAT1 Gain of Function, Type 1 Diabetes, and Reversal with JAK Inhibition