Investigating the protective effects of estrogen on β-cell health and the progression of hyperglycemia-induced atherosclerosis-Reference-Cited by-同舟云学术

Investigating the protective effects of estrogen on β-cell health and the progression of hyperglycemia-induced atherosclerosis

Published:2022-09-01 Issue:3 Volume:323 Page:E254-E266
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

De Paoli Monica¹²,Wood Dempsey W.¹,Bohn Mary K.¹,Pandey Arjun K.¹,Borowitz Dana K.¹,Fang Susanna¹,Patel Zinal¹,Venegas-Pino Daniel E.¹²,Shi Yuanyuan¹,Werstuck Geoff H.¹²^ORCID

Affiliation:

1. Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada

2. Department of Medicine, McMaster University, Hamilton, Ontario, Canada

Abstract

This study examines the effect(s) of estrogen on β cell and cardiometabolic health/function in a novel mouse model of hyperglycemia-induced atherosclerosis ( ApoE−/−: Ins2+/Akita). Using a combination of estrogen deprivation (ovariectomy) and supplementation strategies, we quantify effects on glucose homeostasis and atherogenesis. Our results clearly show a protective role for estrogen on pancreatic β-cell health and function and glucose homeostasis. Furthermore, estrogen supplementation dramatically reduces atherosclerosis progression in both male and female mice.

Funder

Gouvernement du Canada | Canadian Institutes of Health Research

Heart and Stroke Foundation of Canada

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00353.2021

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