Intestinal retinol saturase is implicated in the development of obesity and epithelial homeostasis upon injury-Reference-Cited by-同舟云学术

Intestinal retinol saturase is implicated in the development of obesity and epithelial homeostasis upon injury

Published:2024-08-01 Issue:2 Volume:327 Page:E203-E216
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Kiefer Marie F.¹²^ORCID,Meng Yueming¹,Yang Na¹,Vahrenbrink Madita¹,Wulff Sascha¹,Li Chen¹,Wowro Sylvia J.¹,Petricek Konstantin M.¹^ORCID,Sommerfeld Manuela¹,Flores Roberto E.¹,Obermayer Benedikt³,Piepelow Karolin⁴,Klaus Susanne⁴⁵,Hartl Kimberly⁶⁷,Guillot Adrien⁶,Tacke Frank⁶^ORCID,Sigal Michael⁶⁷^ORCID,Schupp Michael¹^ORCID

Affiliation:

1. Max Rubner Center (MRC) for Cardiovascular Metabolic Renal Research, Institute of Pharmacology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany

2. Bioanalytics Unit, Institute of Biotechnology, Technische Universität Berlin, Berlin, Germany

3. Core Unit Bioinformatics, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Berlin, Germany

4. Department of Physiology of Energy Metabolism, German Institute of Human Nutrition (DIfE) Potsdam-Rehbrücke, Nuthetal, Germany

5. Institute of Nutritional Science, University of Potsdam, Potsdam, Germany

6. Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum (CVK) and Campus Charité Mitte (CCM), Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

7. Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), Berlin, Germany

Abstract

Retinol saturase (RetSat) is an oxidoreductase with unknown function in the intestine. We found that RetSat localizes in intestinal epithelial cells and that its deletion reduced weight gain and fat mass in obese mice. In colitis, which decreased intestinal RetSat expression in humans and mice, RetSat ablation improved the epithelial architecture of the murine colon, presumably by decreasing ROS production, thus rendering RetSat a novel target for metabolic and inflammatory bowel disease.

Funder

Deutsche Forschungsgemeinschaft

Medical School - Charité - University Medicine Berlin | Einstein Centrum für Regenerartive Therapien, Charité-Universitätsmedizin Berlin

Chinese Scholarship Council

Sonnenfeld Stiftung

Berlin School of Integrative Oncology

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00035.2024

Reference77 articles.

1. Identification of All-trans-Retinol:All-trans-13,14-dihydroretinol Saturase

2. Specificity of Zebrafish Retinol Saturase: Formation of All-trans-13,14-dihydroretinol and All-trans-7,8- dihydroretinol

3. Stereospecificity of Retinol Saturase: Absolute Configuration, Synthesis, and Biological Evaluation of Dihydroretinoids

4. Metabolism and Transactivation Activity of 13,14-Dihydroretinoic Acid

5. 9-cis-13,14-Dihydroretinoic Acid Is an Endogenous Retinoid Acting as RXR Ligand in Mice