Effects of interleukin-15 on autophagy regulation in the skeletal muscle of mice-Reference-Cited by-同舟云学术

Effects of interleukin-15 on autophagy regulation in the skeletal muscle of mice

Published:2024-03-01 Issue:3 Volume:326 Page:E326-E340
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Tanaka Minoru¹²³^ORCID,Sugimoto Ken⁴,Akasaka Hiroshi¹^ORCID,Yoshida Shino¹,Takahashi Toshimasa¹,Fujimoto Taku¹,Xie Keyu¹,Yasunobe Yukiko¹,Yamamoto Koichi¹,Hirabayashi Takumi²,Nakanishi Ryosuke²^ORCID,Fujino Hidemi²^ORCID,Rakugi Hiromi¹⁵^ORCID

Affiliation:

1. Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Osaka, Japan

2. Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences, Kobe, Japan

3. Department of Rehabilitation Science, Osaka Health Science University, Osaka, Japan

4. Department of General and Geriatric Medicine, Kawasaki Medical School, Okayama, Japan

5. Osaka Rosai Hospital, Osaka, Japan

Abstract

IL-15 gene deficiency can decrease autophagy induction. However, although IL-15 overexpression induced a decrease in muscle mass, it led to an improvement in muscle quality. Based on these results, understanding the role of IL-15 in regulating autophagy pathways within skeletal muscle may lead to the development of therapies for the autophagy-induced regulation of skeletal muscle mass and cellular quality control.

Funder

MEXT | Japan Society for the Promotion of Science

Japan Society for the Promotion of Science

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00311.2023

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