Acute binge alcohol alters whole body metabolism and the time-dependent expression of skeletal muscle-specific metabolic markers for multiple days in mice

Author:

Tice Abigail L.1,Laudato Joseph A.1,Fadool Debra A.2ORCID,Gordon Bradley S.13ORCID,Steiner Jennifer L.13ORCID

Affiliation:

1. Department of Nutrition and Integrative Physiology, Florida State University, Tallahassee, Florida

2. Department of Biological Science, Program in Neuroscience, and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida

3. Institute of Sports Sciences and Medicine, Florida State University, Tallahassee, Florida

Abstract

Herein, we demonstrate that acute alcohol intoxication immediately alters whole body metabolism coinciding with rapid changes in the skeletal muscle macronutrient gene signature for at least 48 h postbinge and that this response diverges from hepatic effects and those of a fasted animal.

Funder

Florida State University

HHS | NIH | National Institute on Deafness and Other Communication Disorders

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

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