Amino acids differ in their capacity to stimulate GLP-1 release from the perfused rat small intestine and stimulate secretion by different sensing mechanisms-Reference-Cited by-同舟云学术

Amino acids differ in their capacity to stimulate GLP-1 release from the perfused rat small intestine and stimulate secretion by different sensing mechanisms

Published:2021-05-01 Issue:5 Volume:320 Page:E874-E885
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Modvig Ida Marie¹²^ORCID,Kuhre Rune Ehrenreich¹²,Jepsen Sara Lind¹²,Xu Stella Feng Sheng¹²,Engelstoft Maja Storm¹,Egerod Kristoffer Lihme¹,Schwartz Thue Walther¹,Ørskov Cathrine²,Rosenkilde Mette Marie²,Holst Jens Juul¹²

Affiliation:

1. Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

2. Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Abstract

Using isolated perfused rat small intestines, we show that amino acids differ in their mechanisms and capacity of stimulating GLP-1 release. Furthermore, we demonstrate that sensing by GPR142, GPR35, GPR93, and the umami taste receptor (Tas1R1/Tas1R3) are not involved in amino acid stimulated GLP-1 release. In contrast to previous studies, this experimental model allows discrimination between the luminal and the vascular side of the intestine, which is essential when studying mechanisms of amino acid-stimulated GLP-1 secretion.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00026.2021

Reference61 articles.

1. Incretin and islet hormonal responses to fat and protein ingestion in healthy men

2. Peptide YY, Glucagon-Like Peptide-1, and Neurotensin Responses to Luminal Factors in the Isolated Vascularly Perfused Rat Ileum

3. Glucagon-like peptide-1(7–36)amide and glucose-dependent insulinotropic polypeptide secretion in response to nutrient ingestion in man: acute post-prandial and 24-h secretion patterns

4. Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects

5. Glucagon-Like Peptide-1 and Glucose-Dependent Insulin-Releasing Polypeptide Plasma Levels in Response to Nutrients

Cited by 32 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Intraduodenal calcium enhances the effects of L-tryptophan to stimulate gut hormone secretion and suppress energy intake in healthy males: a randomized, crossover, clinical trial;The American Journal of Clinical Nutrition;2024-09

2. Mechanistic Insights into Di-2-ethylhexyl Phthalate (DEHP)-Induced Metabolic Disruption: Integrating Gut Hormone Secretion and Metabolomics in Colonic Organoids;Environmental Science & Technology Letters;2024-08-22

3. Upper-Gastrointestinal Tract Metabolite Profile Regulates Glycaemic and Satiety Responses to Meals with Contrasting Structure;2024-07-02

4. l-valine is a powerful stimulator of GLP-1 secretion in rodents and stimulates secretion through ATP-sensitive potassium channels and voltage-gated calcium channels;Nutrition & Diabetes;2024-06-11

5. Dietary impact on fasting and stimulated GLP-1 secretion in different metabolic conditions – a narrative review;The American Journal of Clinical Nutrition;2024-03