Effects of acute changes in fasting glucose and free fatty acid concentrations on indices of β-cell function and glucose metabolism in subjects without diabetes-Reference-Cited by-同舟云学术

Effects of acute changes in fasting glucose and free fatty acid concentrations on indices of β-cell function and glucose metabolism in subjects without diabetes

Published:2023-08-01 Issue:2 Volume:325 Page:E119-E131
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Schembri Wismayer Daniel¹,Laurenti Marcello C.²^ORCID,Song Yilin¹,Egan Aoife M.¹,Welch Andrew A.¹,Bailey Kent R.³,Cobelli Claudio⁴,Dalla Man Chiara⁵^ORCID,Jensen Michael D.¹^ORCID,Vella Adrian¹^ORCID

Affiliation:

1. Division of Endocrinology, Diabetes & Metabolism, Mayo Clinic College of Medicine, Rochester, Minnesota, United States

2. Biomedical Engineering and Physiology Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Rochester, Minnesota, United States

3. Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States

4. Department of Woman and Child’s Health, University of Padova, Padova, Italy

5. Department of Information Engineering, University of Padova, Padova, Italy

Abstract

This experiment studied the effect of changes in overnight concentrations of free fatty acids (FFAs) and glucose on β-cell function and glucose metabolism. In response to elevation of these metabolites, the dynamic component of the β-cell response to glucose was impaired. This suggests that in health overnight hyperglycemia and FFA elevation can deplete preformed insulin granules in the β-cell.

Funder

HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00043.2023

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