Saturated fat ingestion stimulates proatherogenic inflammation in polycystic ovary syndrome-Reference-Cited by-同舟云学术

Saturated fat ingestion stimulates proatherogenic inflammation in polycystic ovary syndrome

Published:2021-11-01 Issue:5 Volume:321 Page:E689-E701
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

González Frank¹,Considine Robert V.²,Abdelhadi Ola A.³,Xue Jiaping¹,Acton Anthony J.²

Affiliation:

1. Department of Obstetrics and Gynecology, University of Illinois Chicago College of Medicine, Chicago, Illinois

2. Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana

3. Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana

Abstract

This paper demonstrates that in polycystic ovary syndrome (PCOS), ingestion of saturated fat triggers a molecular pathway of inflammation known to drive atherogenesis. This effect is independent of obesity as it occurs in lean women with PCOS and not in lean ovulatory control subjects. Furthermore, the combined effects of PCOS and obesity are greater compared with obesity alone.

Funder

HHS | NIH | National Center for Advancing Translational Sciences

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00213.2021

Reference64 articles.

1. The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria

2. Consensus on women’s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group