The role of interleukin-10 in mitigating endoplasmic reticulum stress in aged mice through exercise-Reference-Cited by-同舟云学术

The role of interleukin-10 in mitigating endoplasmic reticulum stress in aged mice through exercise

Published:2024-09-01 Issue:3 Volume:327 Page:E384-E395
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Marafon Bruno Brieda¹,Pinto Ana Paula²,de Sousa Neto Ivo Vieira²,da Luz Caroline Mantovani²,Pauli José Rodrigo³^ORCID,Cintra Dennys Esper³^ORCID,Ropelle Eduardo Rochete³,Simabuco Fernando Moreira⁴,Pereira de Moura Leandro³,de Freitas Ellen Cristini²⁵^ORCID,Rivas Donato Americo⁶^ORCID,da Silva Adelino Sanchez Ramos¹²^ORCID

Affiliation:

1. Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, University of São Paulo (USP), São Paulo, Brazil

2. School of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), São Paulo, Brazil

3. School of Applied Sciences, University of Campinas (UNICAMP), São Paulo, Brazil

4. Department of Biochemistry, Federal University of São Paulo (UNIFESP), Sao Paulo, Brazil

5. Department of Health Science, Ribeirao Preto, Medical School, University of Sao Paulo (USP), Sao Paulo, Brazil

6. Center for Exercise Medicine Research, Fralin Biomedical Research Institute, Virginia Tech Carilion, Roanoke, Virginia, United States

Abstract

Aging elevates endoplasmic reticulum (ER) stress in skeletal muscle, potentially heightening inflammation by opposing interleukin-10 (IL-10) effects. This study found that short-term combined exercise boosted strength and IL-10 protein levels while reducing CHOP protein levels in older mice. In addition, IL-10-deficient mice exhibited increased ER stress markers, highlighting IL-10’s role in regulating ER stress in skeletal muscle. Consequently, combined exercise emerges as a therapeutic intervention to elevate IL-10 and adjust ER stress markers in aging.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00204.2024

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