A new oral model of free fatty acid kinetics to assess lipolysis in subjects with and without type 2 diabetes-Reference-Cited by-同舟云学术

A new oral model of free fatty acid kinetics to assess lipolysis in subjects with and without type 2 diabetes

Published:2023-08-01 Issue:2 Volume:325 Page:E163-E170
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Bonet J.¹^ORCID,Yadav Y.²,Miles J.³,Basu A.²^ORCID,Cobelli C.⁴,Basu R.²,Dalla Man C.¹^ORCID

Affiliation:

1. Department of Information Engineering, University of Padova, Padova, Italy

2. Division of Endocrinology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, United States

3. University of Kansas Medical Center, Kansas City, Kansas, United States

4. Department of Woman and Child’s Health, University of Padova, Padova, Italy

Abstract

In this study, we propose a new mathematical model able to quantify postprandial FFA kinetics and adipose tissue insulin sensitivity in both subjects with obesity without type 2 diabetes (ND) and subjects with type 2 diabetes (T2D). Results show that the slower postprandial suppression of lipolysis in T2D contributes to the higher free fatty acid (FFA) concentration that, in turn, may contribute to hyperglycemia.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00091.2023

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