Chronic high-fat feeding and prolonged fasting in liver-specific ANGPTL4 knockout mice-Reference-Cited by-同舟云学术

Chronic high-fat feeding and prolonged fasting in liver-specific ANGPTL4 knockout mice

Published:2021-10-01 Issue:4 Volume:321 Page:E464-E478
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Spitler Kathryn M.¹^ORCID,Shetty Shwetha K.¹,Cushing Emily M.¹,Sylvers-Davie Kelli L.¹,Davies Brandon S. J.¹^ORCID

Affiliation:

1. Department of Biochemistry, Fraternal Order of Eagles Diabetes Research Center, and Obesity Research and Education Initiative, University of Iowa, Iowa City, Iowa

Abstract

1) Angiopoietin-like 4 deficiency in hepatocytes ( Angptl4LivKO) does not improve triglyceride phenotypes during high-fat feeding. 2) Angptl4LivKO mice have improved glucose tolerance after chronic high-fat diet. 3) Angptl4LivKO mice have decreased fasting plasma triglyceride levels after an 18-h fast, but not after a 6-h fast.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00144.2021

Reference39 articles.

1. Pathophysiology of Human Visceral Obesity: An Update

2. The interaction of hepatic lipid and glucose metabolism in liver diseases

3. Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance