Susceptibility to diet-induced obesity at thermoneutral conditions is independent of UCP1-Reference-Cited by-同舟云学术

Susceptibility to diet-induced obesity at thermoneutral conditions is independent of UCP1

Published:2022-02-01 Issue:2 Volume:322 Page:E85-E100
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Dieckmann Sebastian¹²³,Strohmeyer Akim¹²³,Willershäuser Monja¹²³,Maurer Stefanie F.¹²³,Wurst Wolfgang⁴⁵⁶,Marschall Susan⁷,de Angelis Martin Hrabe⁷⁸⁹,Kühn Ralf⁴,Worthmann Anna¹⁰,Fuh Marceline M.¹⁰,Heeren Joerg¹⁰,Köhler Nikolai¹¹,Pauling Josch K.¹¹,Klingenspor Martin¹²³^ORCID

Affiliation:

1. Chair for Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany

2. EKFZ - Else Kröner Fresenius Center for Nutritional Medicine, Technical University of Munich, Freising, Germany

3. ZIEL - Institute for Food & Health, Technical University of Munich, Freising, Germany

4. Institute of Developmental Genetics, Helmholtz Zentrum München, Germany

5. TUM School of Life Sciences, Technical University of Munich, Freising, Germany

6. German Center for Neurodegenerative Diseases (DZNE), Site Munich, Germany

7. Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany

8. Chair of Experimental Genetics, TUM School of Life Sciences, Technical University of Munich, Freising, Germany

9. German Center for Diabetes Research (DZD), Neuherberg, Germany

10. Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

11. LipiTUM, Chair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Freising, Germany

Abstract

We provide evidence that the abundance of UCP1 does not influence energy metabolism at thermoneutrality studying a novel Cre-mediated UCP1-KO mouse model. This model will be a foundation for a better understanding of the contribution of UCP1 in different cell types or life stages to energy metabolism.

Funder

Deutsche Forschungsgemeinschaft

Else Kröner-Fresenius-Stiftung

European Commission

Agence Nationale de la Recherche

Bavarian State Ministry of Education, Science and the Arts | Elitenetzwerk Bayern

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00278.2021