Metabolic outcomes in obese mice undergoing one-anastomosis gastric bypass (OAGB) with a long or a short biliopancreatic limb-Reference-Cited by-同舟云学术

Metabolic outcomes in obese mice undergoing one-anastomosis gastric bypass (OAGB) with a long or a short biliopancreatic limb

Published:2024-06-01 Issue:6 Volume:326 Page:E819-E831
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Lazaridis Ioannis I.¹²^ORCID,Bosch Angela J. T.³²,Keller Lena³²,Low Andy J. Y.³²,Tamarelle Jeanne⁴,Moser Seraina O.⁵,Winter Denise V.⁵^ORCID,Gómez Cristina⁵,Peterson Caspar J.¹,Schneider Romano¹,Kraljević Marko¹,Odermatt Alex⁵^ORCID,Vonaesch Pascale⁴,Peterli Ralph¹⁶,Delko Tarik⁷,Cavelti-Weder Claudia³²⁸^ORCID

Affiliation:

1. Clarunis, Department of Visceral Surgery, University Center for Gastrointestinal and Liver Diseases, St. Clara Hospital and University Hospital Basel, Basel, Switzerland

2. Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland

3. Department of Biomedicine (DBM), University of Basel, University Hospital Basel, Basel, Switzerland

4. Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland

5. Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland

6. Department of Clinical Research, University of Basel, Basel, Switzerland

7. Chirurgie Zentrum St. Anna, Lucerne, Switzerland

8. Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), Zurich, Switzerland

Abstract

Weight loss following OAGB surgery in obese mice was not influenced by BPL length, but a longer BPL was associated with improved metabolic outcomes, including glucose and lipid homeostasis. These changes could be mediated by bile acids upon altered gut microbiota. Further validation of these findings is required through a randomized human study.

Funder

Freie Akademische Gesellschaft Basel

Nora von Meeuwen-Häfliger Stiftung

Swiss National Science Foundation

Universitätsspital Basel

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00327.2023

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