Effects of thiopental anesthesia on local rates of cerebral protein synthesis in rats-Reference-Cited by-同舟云学术

Effects of thiopental anesthesia on local rates of cerebral protein synthesis in rats

Published:1998-05-01 Issue:5 Volume:274 Page:E852-E859
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Smith C. Beebe¹,Eintrei C.¹,Kang J.¹,Sun Y.¹

Affiliation:

1. Laboratory of Cerebral Metabolism, National Institute of Mental Health, United States Public Health Service, Department of Health and Human Services, Bethesda, Maryland 20892

Abstract

We have examined the effects of a surgical level of thiopental anesthesia in adult male rats on local rates of cerebral protein synthesis with the quantitative autoradiographicl-[1-14C]leucine method. The relative contribution of leucine derived from protein breakdown to the intracellular precursor amino acid pool for protein synthesis was found to be statistically significantly decreased in the anesthetized rats compared with controls. In the brain as a whole and in 30 of the 35 brain regions examined, rates of protein synthesis were decreased (1–11%) in the anesthetized rats. Decreases were statistically significant ( P ≤ 0.05) in the brain as a whole and in six of the regions, and they approached statistical significance in an additional 13 regions, indicating a tendency for a generalized but small effect.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://www.physiology.org/doi/pdf/10.1152/ajpendo.1998.274.5.E852

Reference21 articles.

1. Plasma Levels of Thiopental Necessary for Anesthesia

2. Effect of pentobarbital on amino acid and urea flux in the isolated dog brain

3. Intracerebral injections inhibit amino acid incorporation into brain protein

4. The metabolic activity of the proteins of the brain

Cited by 11 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Combining laser speckle imaging and spatially modulated visible illumination to study the effect of anesthetic drugs on the optical and physiological parameters of brain;Optics Communications;2024-01

2. Increased rates of cerebral protein synthesis in Shank3 knockout mice: Implications for a link between synaptic protein deficit and dysregulated protein synthesis in autism spectrum disorder/intellectual disability;Neurobiology of Disease;2021-01

3. Quantitative Autoradiographic Method for Determination of Regional Rates of Cerebral Protein Synthesis In Vivo;Journal of Visualized Experiments;2019-06-28

4. Propofol Anesthesia Does Not Alter Regional Rates of Cerebral Protein Synthesis Measured with l-[1-11C]Leucine and PET in Healthy Male Subjects;Journal of Cerebral Blood Flow & Metabolism;2009-02-18

5. Regional Rates of Cerebral Protein Synthesis Measured with l-[1-11C]Leucine and PET in Conscious, Young Adult Men: Normal Values, Variability, and Reproducibility;Journal of Cerebral Blood Flow & Metabolism;2008-05-21