Whole body lipid oxidation during exercise is impaired with poor insulin sensitivity but not with obesity per se

Author:

Arad Avigdor D.12,DiMenna Fred J.1ORCID,Kittrell Hannah D.34,Kissileff Harry R.14,Albu Jeanine B.14

Affiliation:

1. Division of Endocrinology, Diabetes and Bone, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York

2. The Integrated Center for Preventive Medicine, Tel Aviv Medical Center, Tel Aviv, Israel

3. The Charles Bronfman Institute for Personalized Medicine, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York

4. The Mount Sinai Morningside Hospital, New York, New York

Abstract

In this study, we have shown that the capacity to oxidize lipid during exercise is influenced by metabolic health of the exerciser regardless of body composition, but not by body composition per se. This observation refutes the belief that a reduced capacity to oxidize lipid is an obligatory characteristic of the overweight/obese condition while supporting the contention that exercise should be prescribed with specificity based on both absence/presence of overweight/obesity and compromise/lack thereof in metabolic health.

Funder

Icahn School of Medicine at Mount Sinai

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

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