Affiliation:
1. Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts
2. Huashan Hospital, Fudan University, Shanghai, China
Abstract
Endothelial cell insulin resistance is a major contributor to the development of diabetic complications. In this study, we have shown that CITED2, a transcriptional coregulator, inhibits endothelial insulin signaling through the PI3K/Akt pathway via repression of HIF-dependent IRS-2 expression, and that deletion of CITED2 enhances insulin signaling. Thus, CITED2 represents a novel and promising target to improve insulin sensitivity in endothelial cells and prevent vascular complications in diabetes.
Funder
Diabetes Research and Wellness Foundation
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases
Iacocca Family Foundation
National Natural Science Foundation of China
Science and Technology Commission of Shanghai Municipality
Publisher
American Physiological Society
Subject
Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism
Cited by
4 articles.
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