Effect of enteral glutamine on leucine, phenylalanine and glutamine metabolism in hypercortisolemic subjects

Author:

Claeyssens Sophie1,Bouteloup-Demange Corinne2,Gachon Pierre2,Hecketsweiler Bernadette1,Lerebours Eric1,Lavoinne Alain1,Déchelotte Pierre1

Affiliation:

1. Groupe de Biochimie et Physiopathologie Digestive et Nutritionnelle and Institut Fédératif de Recherches Multidisciplinaires sur les Peptides No. 23, Facultéde Médecine-Pharmacie, 76183 Rouen Cedex; and

2. Laboratoire de Nutrition Humaine, Université d'Auvergne, Centre de Recherche en Nutrition Humaine, 63000 Clermont-Ferrand, France

Abstract

The effect of enteral Gln on protein and Gln metabolism was investigated during experimental hypercortisolemia. Four groups of subjects that had received corticosteroids and either enteral Gln (0.5 g ⋅ kg−1 ⋅ day−1for 2 days) or isonitrogenous Ala-Gly were studied in a fasted or in a fed state. In either state, enteral Gln, compared with Ala-Gly, induced no statistically significant change in the endogenous rate of Leu appearance, an index of proteolysis, Leu oxidation, and nonoxidative Leu disposal, an index of protein synthesis, as studied by kinetics of [1-13C]Leu. Similar data were obtained from kinetics of [2H5]Phe, resulting in an unchanged protein balance in both cases. In contrast, enteral Gln significantly decreased the endogenous rate of Gln appearance and Gln de novo synthesis in the fed state ( P < 0.05) as estimated by the kinetics of [15N]Gln. This decrease in Gln de novo synthesis induced by Gln could contribute to spare amino acids in hypercatabolic patients.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Cited by 9 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3