Effect of regional hyperemia on myocardial uptake of 2-deoxy-2-[18F]fluoro-d-glucose

Author:

McFalls Edward O.1,Baldwin Douglas1,Marx David1,Fashingbauer Peggy1,Ward Herbert B.1

Affiliation:

1. Division of Cardiology, Veterans Affairs Medical Center, University of Minnesota, Minneapolis, Minnesota 55417

Abstract

2-Deoxy-2-[18F]fluoro-d-glucose (FDG) may be used to predict glucose kinetics when the factor relating differences in transport and phosphorylation between compounds remains constant (“lumped constant”). It is not clear whether hyperemia alters that factor. In anesthetized swine, myocardial FDG uptake was estimated by positron emission tomography, during an intracoronary infusion of either adenosine, ATP, or bradykinin (40 μg ⋅ kg−1 ⋅ min−1, 40 μg ⋅ kg−1 ⋅ min−1, and 2 nmol ⋅ kg 1 ⋅ min 1, respectively; n = 6 for all groups). In controls during normal perfusion ( n = 6), FDG uptake was 0.78 ± 0.32 μmol ⋅ g 1 ⋅ min 1, whereas glucose uptake by Fick was 0.71 ± 0.25 μmol ⋅ g 1 ⋅ min 1( r = 0.73; P < 0.05). Adenosine increased blood flow from 1.29 ± 0.43 to 4.80 ± 2.19 ml ⋅ g 1 ⋅ min 1( P < 0.05) and glucose uptake from 1.16 ± 1.10 to 3.35 ± 2.12 μmol ⋅ g 1 ⋅ min 1( P < 0.05), whereas FDG uptake in the hyperemic region was lower than remote regions (0.46 ± 0.29 and 0.95 ± 0.55 μmol ⋅ g 1 ⋅ min 1, respectively; P < 0.05). In the ATP and bradykinin groups, blood flow increased four- and twofold, respectively, with no net change in glucose uptake. FDG uptake in the hyperemic region was also significantly lower than remote regions. For all animals, the ratio of blood flow in the hyperemic region relative to remote region was inversely proportional to the ratio of FDG uptake in the same regions ( r 2=0.73; P < 0.001). Because nitric oxide elaboration during hyperemia could potentially alter substrate preference and FDG kinetics, six additional swine were studied during maximal adenosine before and after intracoronary N G-monomethyl-l-arginine (1.5 mg/kg). Inhibition of nitric oxide had no effect on either regional myocardial substrate uptake or FDG accumulation. In conclusion, hyperemia decreased regional myocardial FDG uptake relative to normally perfused regions and this effect on the lumped constant was independent of nitric oxide.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

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2. Liver steatosis coexists with myocardial insulin resistance and coronary dysfunction in patients with type 2 diabetes;American Journal of Physiology-Endocrinology and Metabolism;2006-08

3. Variability of insulin-stimulated myocardial glucose uptake in healthy elderly subjects;European Journal of Nuclear Medicine and Molecular Imaging;2002-12-01

4. Effect of flow and vascular heterogeneity on glucose metabolism in isolated dog hearts;Clinical Physiology and Functional Imaging;2002-03

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