Novel model to study the physiological effects of temporary or prolonged sex steroid deficiency in male mice-Reference-Cited by-同舟云学术

Novel model to study the physiological effects of temporary or prolonged sex steroid deficiency in male mice

Published:2021-03-01 Issue:3 Volume:320 Page:E415-E424
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Kim Na Ri¹,Khalil Rougin¹,David Karel¹,Antonio Leen¹,Schollaert Dieter¹,Deboel Ludo¹,Van Herck Erik¹,Wardenier Nele²³,Cools Martine²³,Decallonne Brigitte¹,Claessens Frank⁴,Dubois Vanessa¹^ORCID,Vanderschueren Dirk¹^ORCID

Affiliation:

1. Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium

2. Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium

3. Division of Pediatric Endocrinology, Department of Pediatrics, Ghent University Hospital, Ghent, Belgium

4. Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium

Abstract

We developed a rodent model of chemical castration, which can be used as an alternative to surgical castration. Moreover, the transient nature of the intervention enables to study the effects of delayed puberty and reversibility of sex steroid deficiency.

Funder

Fonds Wetenschappelijk Onderzoek

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00401.2020

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2. Sexual dimorphism in cortical bone size and strength but not density is determined by independent and time-specific actions of sex steroids and IGF-1: Evidence from pubertal mouse models

3. The Genetic Basis of Delayed Puberty