Metabolic responses to intermittent hypoxia are regulated by sex and estradiol in mice-Reference-Cited by-同舟云学术

Metabolic responses to intermittent hypoxia are regulated by sex and estradiol in mice

Published:2021-02-01 Issue:2 Volume:320 Page:E316-E325
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Marcouiller François¹,Jochmans-Lemoine Alexandra¹,Ganouna-Cohen Gauthier¹,Mouchiroud Mathilde²,Laplante Mathieu²^ORCID,Marette André³⁴,Bairam Aida¹,Joseph Vincent¹^ORCID

Affiliation:

1. Faculté de Médecine, Département de Pédiatrie, Axe Pneumologie, Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Quebec, Canada

2. Faculté de Médecine, Département de Médecine, Axe Obésité-Métabolisme, Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Quebec, Canada

3. Faculté de Médecine, Département de Médecine, Axe Cardiologie, Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Quebec, Canada

4. Institut sur la nutrition et les aliments fonctionnels, Université Laval, Quebec, Canada

Abstract

We assessed fasting glycemic control, and tolerance to insulin and glucose in male and female mice exposed to intermittent hypoxia. IH improves glucose tolerance in males but had opposite effects in females. This response was amplified following ovariectomy in females and prevented by estradiol supplementation. Metabolic consequences of IH differ between males and females and are regulated by estradiol in female mice.

Funder

Fondation de l'Institut Universitaire de Cardiologie et Pneumologie de Québec, Université Laval

Gouvernement du Canada | Canadian Institutes of Health Research

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00272.2020

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