Depletion of microglia mitigates cerebrovascular dysfunction in diet-induced obesity mice-Reference-Cited by-同舟云学术

Depletion of microglia mitigates cerebrovascular dysfunction in diet-induced obesity mice

Published:2021-09-01 Issue:3 Volume:321 Page:E367-E375
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Shen Qing¹²,Zhang Guo¹²^ORCID

Affiliation:

1. Key Laboratory of Environmental Health, Ministry of Education, Department of Toxicology, School of Public Health, Tongji Medical College, Wuhan, Hubei, China;

2. Institute for Brain Research, Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology, Wuhan, Hubei, China

Abstract

We reported that microglia, the resident immune cells in the brain, contribute to obesity-related cerebrovascular dysfunction in mice. Moreover, we also showed that excessive IL-18 can lead to vascular dysfunction in mouse brain.

Funder

National Natural Science Foundation of China

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00086.2021

Reference30 articles.

1. Health Effects of Overweight and Obesity in 195 Countries over 25 Years

2. Stroke in the Young: a Global Update

3. Abdominal Obesity and Risk of Ischemic Stroke