Medium-chain triglyceride-specific appetite is regulated by the β-oxidation of medium-chain fatty acids in the liver-Reference-Cited by-同舟云学术

Medium-chain triglyceride-specific appetite is regulated by the β-oxidation of medium-chain fatty acids in the liver

Published:2024-05-01 Issue:5 Volume:326 Page:E735-E746
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Maruyama Tsugunori¹,Matsui Sho¹,Kobayashi Ryosuke²,Horii Takuro²,Oguri Yasuo¹,Tsuzuki Satoshi¹,Horie Takahiro³,Ono Koh³,Hatada Izuho²⁴,Sasaki Tsutomu¹^ORCID

Affiliation:

1. Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan

2. Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan

3. Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan

4. Viral Vector Core, Gunma University Initiative for Advanced Research, Maebashi, Japan

Abstract

Whether and how medium-chain triglyceride (MCT) intake is regulated remains unknown. Here, we showed that mice can discriminate between MCTs and LCTs. Hepatic β-oxidation participates in MCT-specific appetite, and hypothalamic galanin may be one of the factors that regulate MCT intake. Because of the antiobesity effects of MCTs, studying MCT-specific appetite may help combat obesity by promoting the intake of MCTs instead of LCTs.

Funder

Novartis Pharma Foundation

JST SPRING

Food Science Institute Foundation

Foundation for Dietary Scientific Research

Japan Agency for Medical Research and Development

Japan Foundation for Applied Enzymology

MEXT | Japan Society for the Promotion of Science

Uehara Memorial Foundation

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00031.2024

Reference52 articles.

1. Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

2. A 2022 update on the epidemiology of obesity and a call to action: as its twin COVID-19 pandemic appears to be receding, the obesity and dysmetabolism pandemic continues to rage on

3. OECD 2019 The Heavy Burden of Obesity. Organisation for Economic Co-operation and Development (Online). doi:https://doi.org/10.1787/67450d67-en [2023 Dec 22].

4. Dietary fat and obesity: a review of animal, clinical and epidemiological studies

5. Dietary fat intake does affect obesity!