Unraveling adipose tissue proteomic landscapes in severe obesity: insights into metabolic complications and potential biomarkers-Reference-Cited by-同舟云学术

Unraveling adipose tissue proteomic landscapes in severe obesity: insights into metabolic complications and potential biomarkers

Published:2023-11-01 Issue:5 Volume:325 Page:E562-E580
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Hruska Pavel¹²^ORCID,Kucera Jan³⁴,Kuruczova Daniela³,Buzga Marek⁵⁶,Pekar Matej⁷⁸,Holeczy Pavol⁹¹⁰,Potesil David²,Zdrahal Zbynek²,Bienertova-Vasku Julie¹³⁴

Affiliation:

1. Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic

2. Central European Institute of Technology, Masaryk University, Brno, Czech Republic

3. RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic

4. Department of Physical Activities and Health Sciences, Faculty of Sports Studies, Masaryk University, Brno, Czech Republic

5. Department of Laboratory Medicine, University hospital Ostrava, Ostrava, Czech Republic

6. Department of Physiology and Pathophysiology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic

7. Vascular and Miniinvasive Surgery Center, Hospital AGEL Trinec-Podlesi, Trinec, Czech Republic

8. Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic

9. Department of Surgery, Vitkovice Hospital, Ostrava, Czech Republic

10. Department of Surgical Disciplines, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic

Abstract

This study provides insights into distinct proteomic profiles of subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and serum in patients with severe obesity and their associations with clinical traits and body composition. It underscores SAT’s crucial role in obesity development and related complications, such as insulin resistance (IR) and type 2 diabetes (T2D). Our findings emphasize the importance of understanding the SAT and VAT balance in energy homeostasis, proteostasis, and the potential role of SAT capacity in the development of metabolic disorders.

Funder

Instruct-ERIC

EC | European Regional Development Fund

EC | Horizon 2020 Framework Programme

Ministerstvo Školství, Mládeže a Tělovýchovy

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00153.2023

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