Impact of the trans-ancestry polygenic risk score on type 2 diabetes risk, onset age and progression among population in Taiwan-Reference-Cited by-同舟云学术

Impact of the trans-ancestry polygenic risk score on type 2 diabetes risk, onset age and progression among population in Taiwan

Published:2024-05-01 Issue:5 Volume:326 Page:E547-E554
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Wang Shi-Heng¹²,Huang Yu-Chuen³⁴,Cheng Chun-Wen⁵⁶,Chang Ya-Wen⁴⁷⁸,Liao Wen-Ling⁷⁸^ORCID

Affiliation:

1. National Center for Geriatrics and Welfare Research, National Health Research Institutes, Zhunan, Taiwan

2. Department of Public Health, China Medical University, Taichung, Taiwan

3. School of Chinese Medicine, China Medical University, Taichung, Taiwan

4. Genetic Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan

5. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan

6. Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan

7. Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan

8. Center for Personalized Medicine, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan

Abstract

Our findings indicated that diabetic polygenic risk score (PRS) which combined susceptibility variants from Asian and European population affect the onset age of type 2 diabetes (T2D) and could be used as a tool for early screening of T2D, especially for individuals with high genetic risk, and may be associated with the risk of diabetic complications among people in Taiwan.

Funder

China Medical University Hospital

National Science and Technology Council

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00252.2023

Reference62 articles.

1. A high incidence of type 1 diabetes and an alarming increase in the incidence of type 2 diabetes among young adults in Finland between 1992 and 1996

2. Proportion of Diabetes Type in Early-Onset Diabetes in Japan

3. Increasing incidence of diagnosed type 2 diabetes in Taiwan: analysis of data from a national cohort

4. Changes in Age at Diagnosis of Type 2 Diabetes Mellitus in the United States, 1988 to 2000

5. International Diabetes Federation. International Diabetes Federation Diabetes Atlas (7th ed.). International Diabetes Federation, 2015.