Integration of metabolic flux with hepatic glucagon signaling and gene expression profiles in the conscious dog-Reference-Cited by-同舟云学术

Integration of metabolic flux with hepatic glucagon signaling and gene expression profiles in the conscious dog

Published:2024-04-01 Issue:4 Volume:326 Page:E428-E442
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Coate Katie C.¹^ORCID,Ramnanan Christopher J.²,Smith Marta³,Winnick Jason J.⁴,Kraft Guillaume³^ORCID,Irimia-Dominguez Jose⁵,Farmer Ben³,Donahue E. Patrick¹,Roach Peter J.⁶,Cherrington Alan D.³^ORCID,Edgerton Dale S.³^ORCID

Affiliation:

1. Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States

2. Department of Innovation in Medical Education, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada

3. Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States

4. Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States

5. Department of Molecular and Cellular Endocrinology, Beckman Research Institute, Duarte, California, United States

6. Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States

Abstract

Glucagon rapidly stimulates hepatic glucose production, but these effects are transient. This study links the molecular and metabolic flux changes that occur in the liver over time in response to a rise in glucagon, demonstrating the strength of the dog as a translational model to couple findings in small animals and humans. In addition, this study clarifies why the rapid effects of glucagon on liver glycogen metabolism are not sustained.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

American Diabetes Association

Vanderbilt Jacquelyn A. Turner and Dr. Dorothy J. Turner Chair in Diabetes Research

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00316.2023

Reference81 articles.

1. Influence of somatostatin on splanchnic glucose metabolism in postabsorptive and 60-hour fasted humans.

2. Glucagon is a primary controller of hepatic glycogenolysis and gluconeogenesis during muscular work

3. Insulin, glucagon, and catecholamines in prevention of hypoglycemia during fasting

4. Role of Glucagon, Catecholamines, and Growth Hormone in Human Glucose Counterregulation

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Glucagon infusion alters the circulating metabolome and urine amino acid excretion in dogs;Journal of Endocrinology;2024-05-30