RORα contributes to the maintenance of genome ploidy in the liver of mice with diet-induced nonalcoholic steatohepatitis-Reference-Cited by-同舟云学术

RORα contributes to the maintenance of genome ploidy in the liver of mice with diet-induced nonalcoholic steatohepatitis

Published:2022-02-01 Issue:2 Volume:322 Page:E118-E131
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Kim Ju-Yeon¹,Yang In Sook²,Kim Hyeon-Ji¹³,Yoon Jae-Yeun¹,Han Yong-Hyun⁴,Seong Je Kyung²⁵⁶,Lee Mi-Ock¹³⁷⁶^ORCID

Affiliation:

1. College of Pharmacy, Seoul National University, Seoul, South Korea

2. College of Veterinary Medicine, Seoul National University, Seoul, South Korea

3. Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, South Korea

4. College of Pharmacy, Kangwon National University, Chuncheon, South Korea

5. Research Institute of Veterinary Science, Seoul National University, Seoul, South Korea

6. Korea Mouse Phenotyping Center, Seoul National University, Seoul, South Korea

7. Bio-MAX Institute, Seoul National University, Seoul, South Korea

Abstract

It has been reported that hepatic polyploidization is closely linked to the progression of NAFLD. Here, we showed that the genetic depletion of hepatic RORα in mice accelerated hepatocyte polyploidization after high-fat diet feeding. The mechanism could be the RORα-mediated repression of E2f7 and E2f8, key transcription factors for DNA endoreplication. Thus, preservation of genome integrity by RORα could provide a new insight for developing therapeutics against the disease.

Funder

Korea Mouse Phenotyping Project

National Research Foundation of Korea

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00309.2021

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