GLP1 receptor agonism protects against acute olanzapine-induced hyperglycemia-Reference-Cited by-同舟云学术

GLP1 receptor agonism protects against acute olanzapine-induced hyperglycemia

Published:2020-12-01 Issue:6 Volume:319 Page:E1101-E1111
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Medak Kyle D.¹,Shamshoum Hesham¹,Peppler Willem T.¹,Wright David C.¹

Affiliation:

1. Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada

Abstract

Antipsychotic drugs cause rapid perturbations in glucose and lipid metabolism. In the present study we have demonstrated that cotreatment with glucagon-like peptide 1 (GLP1) receptor agonists, such as liraglutide, protects against metabolic dysregulation caused by the antipsychotic drug olanzapine. These findings suggest that pharmacological targeting of the GLP1 receptor could be an effective adjunct approach to mitigate the harmful acute metabolic side effects of antipsychotic drugs.

Funder

Gouvernement du Canada | Canadian Institutes of Health Research

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00309.2020

Reference72 articles.

1. GLP-1-based therapy of type 2 diabetes: GLP-1 mimetics and DPP-IV inhibitors

2. A Double Blind, Placebo-Controlled, Randomized Crossover Study of the Acute Metabolic Effects of Olanzapine in Healthy Volunteers

3. Brain stem as a target site for the metabolic side effects of olanzapine

4. Liraglutide prevents metabolic side-effects and improves recognition and working memory during antipsychotic treatment in rats

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