Kruppel-like factor 14 ameliorated obesity and related metabolic disorders by promoting adipose tissue browning-Reference-Cited by-同舟云学术

Kruppel-like factor 14 ameliorated obesity and related metabolic disorders by promoting adipose tissue browning

Published:2023-12-01 Issue:6 Volume:325 Page:E744-E754
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Mao Xiaoxiang¹²^ORCID,Li Yuanxiang³,Zhong Yi²,Chen Ru¹²,Wang Kun⁴,Huang Dandan¹²,Luo Xi¹²^ORCID

Affiliation:

1. Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China

2. Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China

3. Department of Oncology, Hubei Cancer Hospital, TongJi Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China

4. Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China

Abstract

Our study first explored the role of KLF14 in the development and progression of HFD-induced obesity in male mice. Its beneficial effect on adipose browning and metabolic disorders suggests that KLF14 may provide us a new therapeutic strategy for obesity and related metabolic complications. This health problem is of global concern and needs to be addressed.

Funder

MOST | National Natural Science Foundation of China

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00226.2023

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