Effects of exogenous lactate on lipid, protein, and glucose metabolism—a randomized crossover trial in healthy males-Reference-Cited by-同舟云学术

Effects of exogenous lactate on lipid, protein, and glucose metabolism—a randomized crossover trial in healthy males

Published:2024-04-01 Issue:4 Volume:326 Page:E443-E453
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Pedersen Mette G. B.¹²^ORCID,Rittig Nikolaj¹²^ORCID,Bangshaab Maj¹²,Berg-Hansen Kristoffer³,Gopalasingam Nigopan³,Gormsen Lars C.⁴^ORCID,Søndergaard Esben¹^ORCID,Møller Niels¹²

Affiliation:

1. Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark

2. Medical Research Laboratory, Aarhus University, Aarhus, Denmark

3. Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark

4. Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus, Denmark

Abstract

Lactate is a decisive intermediary metabolite, serving as an energy substrate and a signaling molecule. The present study examines the effects of lactate on substrate metabolism and insulin sensitivity in healthy males. Hyperlactatemia reduces lipolysis by 30% without affecting insulin sensitivity and glucose metabolism. In addition, hyperlactatemia increases whole body amino acid turnover rate.

Funder

Novo Nordisk Fonden

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00301.2023

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