Congenital ablation of Tacr2 reveals overlapping and redundant roles of NK2R signaling in the control of reproductive axis-Reference-Cited by-同舟云学术

Congenital ablation of Tacr2 reveals overlapping and redundant roles of NK2R signaling in the control of reproductive axis

Published:2021-03-01 Issue:3 Volume:320 Page:E496-E511
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Torres Encarnacion¹²,Velasco Inmaculada¹²,Franssen Delphine¹²,Heras Violeta¹²,Gaytan Francisco¹²,Leon Silvia¹²³,Navarro Victor M.³,Pineda Rafael¹²,Candenas M. Luz⁴,Romero-Ruiz Antonio¹²,Tena-Sempere Manuel¹²⁵^ORCID

Affiliation:

1. Department of Cell Biology, Physiology and Immunology, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), University of Córdoba, Córdoba, Spain

2. CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain

3. Division of Endocrinology, Department of Medicine, Diabetes, and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts

4. Instituto de Investigaciones Químicas, CSIC, Seville, Spain

5. Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine and Turku Center for Disease Modeling, University of Turku, Turku, Finland

Abstract

We have explored here the impact of congenital ablation of the gene ( Tacr2) encoding the tachykinin receptor, NK2R, in terms of neuroendocrine control of the reproductive axis, using a novel Tacr2 KO mouse line. Our data support a modest, albeit detectable, role of NK2R in the control of the gonadotropic axis, with partially overlapping and redundant functions with other tachykinin receptors.

Funder

EC | Horizon 2020

Ministerio de Economía y Competitividad

MEC | Instituto de Salud Carlos III

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00346.2020

Reference59 articles.

1. Control of puberty onset and fertility by gonadotropin-releasing hormone neurons