Human pancreatic capillaries and nerve fibers persist in type 1 diabetes despite beta cell loss-Reference-Cited by-同舟云学术

Human pancreatic capillaries and nerve fibers persist in type 1 diabetes despite beta cell loss

Published:2023-03-01 Issue:3 Volume:324 Page:E251-E267
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Richardson Tiffany M.¹^ORCID,Saunders Diane C.²^ORCID,Haliyur Rachana¹³^ORCID,Shrestha Shristi²⁴^ORCID,Cartailler Jean-Philippe⁴^ORCID,Reinert Rachel B.⁵⁶^ORCID,Petronglo Jenna⁷^ORCID,Bottino Rita⁸^ORCID,Aramandla Radhika²,Bradley Amber M.²^ORCID,Jenkins Regina²,Phillips Sharon⁹^ORCID,Kang Hakmook⁹^ORCID,Caicedo Alejandro¹⁰¹¹¹²^ORCID,Powers Alvin C.¹²¹³^ORCID,Brissova Marcela²^ORCID,

Affiliation:

1. Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States

2. Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States

3. Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, United States

4. Creative Data Solutions, Vanderbilt Center for Stem Cell Biology, Nashville, Tennessee, United States

5. Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States

6. Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, United States

7. Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States

8. Imagine Pharma, Pittsburgh, Pennsylvania, United States

9. Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, United States

10. Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, United States

11. Program of Neuroscience, University of Miami Miller School of Medicine, Miami, Florida, United States

12. Department of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, Florida, United States

13. Department of Veterans Affairs Tennessee Valley Healthcare, Nashville, Tennessee, United States

Abstract

Defining the neurovascular architecture in the pancreas of individuals with type 1 diabetes (T1D) is crucial to understanding the mechanisms of dysregulated glucagon secretion. In the largest T1D cohort of biobanked tissues analyzed to date, we found that pancreatic capillaries and nerve fibers persist in human T1D despite beta cell loss, suggesting that alpha cell secretory changes may be decoupled from neurovascular components. Because innervation has been studied extensively in rodent T1D models, our studies also provide the first rigorous direct comparisons of neurovascular assembly in mouse and human, indicating dramatic interspecies differences.

Funder

HHS | NIH | National Cancer Institute

HHS | NIH | National Eye Institute

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Human Islet Research Network

Juvenile Diabetes Research Foundation United States of America

Leona M. and Harry B. Helmsley Charitable Trust

National Science Foundation

U.S. Department of Veterans Affairs

Human Pancreas Analysis Program

Publisher

American Physiological Society