Activation of RAGE-dependent endoplasmic reticulum stress associates with exacerbated postmyocardial infarction ventricular arrhythmias in diabetes-Reference-Cited by-同舟云学术

Activation of RAGE-dependent endoplasmic reticulum stress associates with exacerbated postmyocardial infarction ventricular arrhythmias in diabetes

Published:2021-03-01 Issue:3 Volume:320 Page:E539-E550
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Liu Zhongwei¹,Zhang Yong¹,Pan Shuo¹,Qiu Chuan²^ORCID,Jia Hao³,Wang Yuan⁴,Zhu Haitao⁵

Affiliation:

1. Department of Cardiology, Affiliated Shaanxi Provincial People’s Hospital, Northwestern Polytechnical University, Xi’an, People’s Republic of China

2. Department of Global Biostatistics and Data Science, School of Public Health and Tropical Medicine, Center for Bioinformatics and Genomics, Tulane University, New Orleans, Louisiana

3. International Medical Services, Affiliated Hospital of Northwest University, Northwest University, Xi’an, People’s Republic of China

4. Department of Medical Prevention, Affiliated Shaanxi Provincial People’s Hospital, Northwestern Polytechnical University, Xi’an, People’s Republic of China

5. Department of Pediatrics, Northwest Women’s and Children’s Hospital, Xi’an, People’s Republic of China

Abstract

In this study, we proposed a possible mechanism interpreting the clinical scenario that after myocardial infarction (MI) patients were more vulnerable to ventricular arrhythmias (VAs) when complicated with diabetes. A cohort study revealed that advanced glycation end products (AGEs) accumulated in patients with diabetes and closely associated post-MI VAs. In vivo and in vitro studies indicated that receptor for AGEs (RAGE)-dependent endoplasmic reticulum (ER) stress protein kinase RNA-like ER kinase (PERK) pathway triggered VAs, via ER calcium releasing, through calcineurin/RyR2 mechanism.

Funder

Health Research Foundation of Shaanxi Province

Innovative Talents Promotion Project of Shaanxi Province

National Natural Science Foundation of China

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00450.2020

Reference40 articles.

1. n-3 Fatty Acids, Ventricular Arrhythmia–Related Events, and Fatal Myocardial Infarction in Postmyocardial Infarction Patients With Diabetes