Efferent synaptic transmission at the vestibular type II hair cell synapse-Reference-Cited by-同舟云学术

Efferent synaptic transmission at the vestibular type II hair cell synapse

Published:2020-08-01 Issue:2 Volume:124 Page:360-374
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Yu Zhou¹²,McIntosh J. Michael³,Sadeghi Soroush G.⁴⁵^ORCID,Glowatzki Elisabeth¹²^ORCID

Affiliation:

1. Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland

2. Department of Otolaryngology-Head and Neck Surgery, The Center for Hearing and Balance, and The Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland

3. George E. Wahlen Veterans Affairs Medical Center, Salt Lake City, Utah

4. Department of Communicative Disorders and Sciences, and Center for Hearing and Deafness, State University of New York at Buffalo, Buffalo, New York

5. Neuroscience Program, State University of New York at Buffalo, Buffalo, New York

Abstract

Type II vestibular hair cells (HCs) receive inputs from efferent neurons in the brain stem. We used in vitro optogenetic and electrical stimulation of vestibular efferent fibers to study their synaptic inputs to type II HCs. Stimulation of efferents inhibited type II HCs, similar to efferent effects on cochlear HCs. We propose that efferent inputs adjust the contribution of signals from type I and II HCs to vestibular nerve fibers.

Funder

HHS | NIH | National Institute on Deafness and Other Communication Disorders

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00143.2020

Reference115 articles.

1. Multipotent Myoepithelial Progenitor Cells Are Born Early during Airway Submucosal Gland Development

2. Efferent regulation of hair cells in the turtle cochlea