Electrophysiological and pharmacological characterization of spreading depolarization in the adult zebrafish tectum-Reference-Cited by-同舟云学术

Electrophysiological and pharmacological characterization of spreading depolarization in the adult zebrafish tectum

Published:2021-12-01 Issue:6 Volume:126 Page:1934-1942
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Terai Haruhi¹,Gwedela Mayeso Naomi Victoria¹,Kawakami Koichi²,Aizawa Hidenori¹^ORCID

Affiliation:

1. Department of Neurobiology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

2. Laboratory of Molecular and Developmental Biology, National Institute of Genetics and Department of Genetics, SOKENDAI (The Graduate University for Advanced Studies), Shizuoka, Japan

Abstract

Previous studies have implicated spreading depolarization (SD) in stroke and migraine. Here, we demonstrate SD, for the first time, in the adult zebrafish tectum showing waveform kinetics, c-fos expression, and attenuation by N-methyl-d-aspartate glutamate receptor blocker as observed in the rodent cortex. Since the zebrafish is an animal model amenable to genetic manipulation and chemical screening, this result could pave the way to novel diagnostic and therapeutic methods applicable to SD-associated neurological disorders.

Funder

MEXT | Japan Society for the Promotion of Science

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00343.2021

Reference31 articles.

1. Chaos and commotion in the wake of cortical spreading depression and spreading depolarizations

2. The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease

3. Mechanisms of Spreading Depression and Hypoxic Spreading Depression-Like Depolarization

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5. Familial Hemiplegic Migraine and Episodic Ataxia Type-2 Are Caused by Mutations in the Ca2+ Channel Gene CACNL1A4

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