The impact of targeted ablation of one row of outer hair cells and Deiters’ cells on cochlear amplification-Reference-Cited by-同舟云学术

The impact of targeted ablation of one row of outer hair cells and Deiters’ cells on cochlear amplification

Published:2022-11-01 Issue:5 Volume:128 Page:1365-1373
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Xia Anping¹,Udagawa Tomokatsu¹²^ORCID,Quiñones Patricia M.³^ORCID,Atkinson Patrick J.¹,Applegate Brian E.³⁴,Cheng Alan G.¹^ORCID,Oghalai John S.³⁴^ORCID

Affiliation:

1. Department of Otolaryngology—Head and Neck Surgery, Stanford University School of Medicine, Stanford, California

2. Department of Otorhinolaryngology, The Jikei University School of Medicine, Tokyo, Japan

3. Caruso Department of Otolaryngology—Head & Neck Surgery, University of Southern California, Los Angeles, California

4. Department of Biomedical Engineering, Denney Research Center (DRB) 140, University of Southern California, Los Angeles, California

Abstract

Normal cochlear physiology involves force production from three rows of outer hair cells to amplify and tune the traveling wave. Here, we used a genetic approach to target and ablate the third row of outer hair cells in the mouse cochlea and found it reduced cochlear amplification by 79%. This means that the loss of even a relatively small number of OHCs, when evenly distributed, causes a substantial reduction in cochlear amplification.

Funder

California Institute of Regenerative Medicine

DOD | USN | BUMED | NMRC | Naval Health Research Center

HHS | NIH | National Institute of Biomedical Imaging and Bioengineering

HHS | NIH | National Institute on Deafness and Other Communication Disorders

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00501.2021

Reference64 articles.

1. Evoked Mechanical Responses of Isolated Cochlear Outer Hair Cells

2. Cochlear amplification, outer hair cells and prestin

3. Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier

4. Integrating the active process of hair cells with cochlear function

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