Effect of size on expression of bistability in mouse spinal motoneurons

Author:

Harris-Warrick Ronald M.1ORCID,Pecchi Emilie2,Drouillas Benoît2,Brocard Frédéric2,Bos Rémi2ORCID

Affiliation:

1. Department of Neurobiology and Behavior, Cornell University, Ithaca, New York, United States

2. Aix Marseille Univ, CNRS, Institut de Neurosciences de la Timone (INT), UMR 7289, Marseille, France

Abstract

Bistability is not a common feature of all mouse spinal motoneurons. It is absent in small, slow motoneurons but present in most large, fast motoneurons. This difference results from differential expression of ionic currents that enable bistability, which are highly expressed in large motoneurons but small or absent in small motoneurons. These results support a possible role for fast motoneurons in maintenance of tonic posture in addition to their known roles in fast movements.

Funder

Fonds d'investissement INT

Agence Nationale de la Recherche Scientifique

Centre National de la Recherche Scientifique

HHS | NIH | National Institute of Neurological Disorders and Stroke

Publisher

American Physiological Society

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