Visual Cortex Neurons of Monkeys and Cats: Temporal Dynamics of the Contrast Response Function

Abstract

Cortical neurons display two fundamental nonlinear response characteristics: contrast-set gain control (also termed contrast normalization) and response expansion (also termed half-squaring). These nonlinearities could play an important role in forming and maintaining stimulus selectivity during natural viewing, but only if they operate well within the time frame of a single fixation. To analyze the temporal dynamics of these nonlinearities, we measured the responses of individual neurons, recorded from the primary visual cortex of monkeys and cats, as a function of the contrast of transient stationary gratings that were presented for a brief interval (200 ms). We then examined 1) the temporal response profile (i.e., the post stimulus time histogram) as a function of contrast and 2) the contrast response function throughout the course of the temporal response. We found that the shape and complexity of the temporal response profile varies considerably from cell to cell. However, within a given cell, the shape remains relatively invariant as a function of contrast and appears to be simply scaled and shifted. Stated quantitatively, approximately 95% of the variation in the temporal responses as a function of contrast could be accounted for by scaling and shifting the average poststimulus time histogram. Equivalently, we found that the overall shape of the contrast response function (measured every 2 ms) remains relatively invariant from the onset through the entire temporal response. Further, the contrast-set gain control and the response expansion are fully expressed within the first 10 ms after the onset of the response. Stated quantitatively, the same, scaled Naka-Rushton equation (with the same half-saturation contrast and expansive response exponent) provides a good fit to the contrast response function from the first 10 ms through the last 10 ms of the temporal response. Based upon these measurements, it appears as though the two nonlinear properties, contrast-set gain control and response expansion, are present in full strength, virtually instantaneously, at the onset of the response. This observation suggests that response expansion and contrast-set gain control can influence the performance of visual cortex neurons very early in a single fixation, based on the contrast within that fixation. In the discussion, we consider the implications of the results within the context of 1) slower types of contrast gain control, 2) discrimination performance, 3) drifting steady-state measurements, 4) functional models that incorporate response expansion and contrast normalization, and 5) structural models of the biochemical and biophysical neural mechanisms.