Dissociating the neural bases of repetition-priming and adaptation in the human brain for faces

Abstract

The repetition of a given stimulus leads to the attenuation of the functional magnetic resonance imaging (fMRI) signal compared with unrepeated stimuli, a phenomenon called fMRI adaptation or repetition suppression (RS). Previous studies have related RS of the fMRI signal behaviorally both to improved performance for the repeated stimulus (priming) and to shifts of perception away from the first stimulus (adaptation-related aftereffects). Here we used identical task (sex discrimination), trial structure [ stimulus 1 (S1): 3,000 ms, interstimulus interval: 600 ms, stimulus 2 (S2): 300 ms], and S2 stimuli (androgynous faces) to test how RS of the face-specific areas of the occipito-temporal cortex relates to priming and aftereffects. By varying S1, we could induce priming (significantly faster reaction times when S1 and S2 were identical compared with different images) as well as sex-specific aftereffect [an increased ratio of male responses if S1 was a female face compared with ambiguous faces or to Fourier-randomized noise (FOU) images]. Presenting any face as S1 led to significant RS of the blood oxygen level-dependent signal in the fusiform and occipital face areas as well as in the lateral occipital cortex of both hemispheres compared with FOU, reflecting stimulus category-specific encoding. Additionally, while sex-specific adaptation effects were only observed in occipital face areas, primed trials led to a signal reduction in both face-selective regions. Altogether, these results suggest the differential neural mechanisms of adaptation and repetition priming.