Deciphering how interneuron specific 3 cells control oriens lacunosum-moleculare cells to contribute to circuit function

Author:

Guet-McCreight Alexandre12ORCID,Skinner Frances K.13ORCID

Affiliation:

1. Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada

2. Department of Physiology, University of Toronto, Toronto, Ontario, Canada

3. Departments of Medicine (Neurology) and Physiology, University of Toronto, Toronto, Ontario, Canada

Abstract

How information is processed across different brain structures is an important question that relates to the different functions that the brain performs. Using modeling and theoretical analyses, we show that an inhibitory cell type that only inhibits other inhibitory cells can broaden the window for disinhibition of excitatory cells, manage input pathway switching, and modulate inhibitory cell spiking. This work contributes to the knowledge of how coordination between sensory and memory consolidation information can be attained.

Funder

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

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