Heritability of brain neurovascular coupling

Author:

Christova Peka12,Uğurbil Kâmil23ORCID,Georgopoulos Apostolos P.12ORCID

Affiliation:

1. Department of Veterans Affairs Health Care System, The Functional Neuroimaging Research Group, Brain Sciences Center, Minneapolis, Minnesota

2. Department of Neuroscience, University of Minnesota Medical School, Minneapolis, Minnesota

3. Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, Minnesota

Abstract

Here we show that the sample-to-sample turnover of the resting state fMRI blood-oxygen-level-dependent turnover (TBOLD) is heritable, the left and right hemisphere TBOLD heritabilities are highly correlated, and TBOLD heritability varies among cortical areas. Moreover, we documented that TBOLD is associated with the regional cortical distribution of the vesicular acetylcholine transporter.

Funder

United States Department of Veterans Affairs

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

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