Persistent and resurgent Na+ currents in vestibular calyx afferents-Reference-Cited by-同舟云学术

Persistent and resurgent Na+ currents in vestibular calyx afferents

Published:2020-08-01 Issue:2 Volume:124 Page:510-524
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Meredith Frances L.¹,Rennie Katherine J.¹²

Affiliation:

1. Department of Otolaryngology, University of Colorado School of Medicine, Aurora, Colorado

2. Department of Physiology & Biophysics, University of Colorado School of Medicine, Aurora, Colorado

Abstract

Action potential firing patterns differ between groups of afferent neurons innervating vestibular epithelia. We investigated the biophysical properties of Na+ currents in specialized vestibular calyx afferent terminals during postnatal development. Mature calyces express Na+ currents with transient, persistent, and resurgent components. Nav1.6 channels contribute to resurgent Na+ currents and may enhance firing in peripheral calyx afferents. Understanding Na+ channels that contribute to vestibular nerve responses has implications for developing new treatments for vestibular dysfunction.

Funder

HHS | NIH | National Institute on Deafness and Other Communication Disorders

American Otological Society

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00124.2020

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